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(2016) Urinary oxidative stress biomarkers among local residents measured 6 year s after the Hebei Spirit oil spill

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  • 등록일 : 2017-06-15
(2016) Urinary oxidative stress biomarkers among local residents measured 6 year s after the Hebei Spirit oil spill

-저널 : Science of the Total Environment
-저자 : 김정아, 노수련, 정해관, 하미나, 박명숙, 추연희, 이승화, 최경호


[Abstract]

In December 2007, the Hebei Spirit oil spill occurred on the west coast of South Korea. Association between crude
oil exposure and the levels of urinary oxidative stress biomarkers was reported among the local residents,
1.5 years after the accident. The aim of this study was to follow-up possible longer-term effects of the oil spill
among the residents near the oil spill. Six years after the accident, urinary oxidative stress biomarkers of the residentswere
associatedwith surrogates of oil exposure. The target subjectswere divided into two groups based on
the distance of their residence to the spill site, i.e., those near the spill site (‘Near’ group, n=476), and those far
fromthe spill (‘Far’ group, n=152). A questionnairewas administered by trained interviewers or self-reporting,
and demographic information and other parameters of the participants, such as socioeconomic status, smoking
and drinking behaviors, disease history, and duration of clean-up activities after the spill,were collected. The participants'
levels of 8–hydroxy–2–deoxyguanosine (8–OHdG) and malondialdehyde (MDA) in 12 h urine samples
were measured as indicators of oxidative DNA damage and lipid peroxidation, respectively. A general linear
model was used for statistical analysis. Urinary MDA and 8-OHdG levels measured from ‘Near’ group, i.e.,